The primary cilium is a sensory organelle
نویسندگان
چکیده
منابع مشابه
Functional Genomics of the Cilium, a Sensory Organelle
Cilia and flagella play important roles in many physiological processes, including cell and fluid movement, sensory perception, and development. The biogenesis and maintenance of cilia depend on intraflagellar transport (IFT), a motility process that operates bidirectionally along the ciliary axoneme. Disruption in IFT and cilia function causes several human disorders, including polycystic kidn...
متن کاملThe primary cilium as the cell's antenna: signaling at a sensory organelle.
Almost every vertebrate cell has a specialized cell surface projection called a primary cilium. Although these structures were first described more than a century ago, the full scope of their functions remains poorly understood. Here, we review emerging evidence that in addition to their well-established roles in sight, smell, and mechanosensation, primary cilia are key participants in intercel...
متن کاملThe perennial organelle: assembly and disassembly of the primary cilium.
Primary cilia contain signaling receptors of diverse classes, and ciliary dysfunction results in a variety of developmental defects. Thus, primary cilia are thought to have an important role in sensing and transducing cellular signals. Although there is clear evidence demonstrating that these organelles are assembled and disassembled dynamically as cells progress through the cell cycle, the mec...
متن کاملInvited Review An incredible decade for the primary cilium: a look at a once-forgotten organelle
Davenport, James R., and Bradley K. Yoder. An incredible decade for the primary cilium: a look at a once-forgotten organelle. Am J Physiol Renal Physiol 289: F1159–F1169, 2005; doi:10.1152/ajprenal.00118.2005.—Since the discovery that numerous proteins involved in mammalian disease localize to the basal bodies and cilia, these organelles have emerged from relative obscurity to the center of int...
متن کاملAn incredible decade for the primary cilium: a look at a once-forgotten organelle.
Since the discovery that numerous proteins involved in mammalian disease localize to the basal bodies and cilia, these organelles have emerged from relative obscurity to the center of intense research efforts in an expanding number of disease- and developmental-related fields. Our understanding of the association between cilia and human disease has benefited substantially from the use of lower ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a346